The effects of magnesium sulfate therapy after severe diffuse axonal injury
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چکیده
منابع مشابه
The effects of magnesium sulfate therapy after severe diffuse axonal injury
PURPOSE To evaluate the clinical effects of magnesium sulfate in the treatment of diffuse axonal injury (DAI). PATIENTS AND METHODS This study was a randomized, double-blind, placebo-controlled trial conducted in the First Affiliated Hospital of Sun Yat-sen University, Guangzhou and Zhuhai People's Hospital, Zhuhai, two trauma center hospitals. A total of 128 patients suffered from DAI, with ...
متن کاملOptimization of magnesium therapy after severe diffuse axonal brain injury in rats.
A number of studies have demonstrated that magnesium salts given after traumatic brain injury improve subsequent neurologic outcome. However, given that these earlier studies have used a number of different salts, dosages, and routes of administration, follow-up studies of the neuroprotective properties of magnesium are complicated, with comparisons to the earlier literature virtually impossibl...
متن کاملmagnesium sulfate effect on the clinical course and gcs of patients with a severe diffuse axonal injury
based on a number of studies, magnesium sulfate (mgso4) given after a diffuse axonal injury has gained attention as a useful neuroprotective agent .the present study was conducted to examine if magnesium sulfate has a therapeutic efficacy and safety in patients with a severe diffuse axonal injury. adult patients admitted within 1 hour of a closed traumatic brain injury (tbi) with a severe diffu...
متن کاملEffects of magnesium sulfate on the clinical course and GCS of patients with a severe diffuse axonal injury
Background: Previous studies have shown that magnesium sulfate (MgSO4) administered in a patient with a diffuse axonal injury (DAI) can serve as a useful neuroprotective agent. The present study was conducted to examine whether magnesium sulfate has a therapeutic efficacy and safety in patients with a severe diffuse axonal injury. Methods: Adult patients admitted within 1 hour of a closed Traum...
متن کاملTherapy development for diffuse axonal injury.
Diffuse axonal injury (DAI) remains a prominent feature of human traumatic brain injury (TBI) and a major player in its subsequent morbidity. The importance of this widespread axonal damage has been confirmed by multiple approaches including routine postmortem neuropathology as well as advanced imaging, which is now capable of detecting the signatures of traumatically induced axonal injury acro...
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ژورنال
عنوان ژورنال: Therapeutics and Clinical Risk Management
سال: 2016
ISSN: 1178-203X
DOI: 10.2147/tcrm.s109482